Yes and No. It is designed to work with any Oracle Database, not the E-Business Suite in particular.  However, it may be installed into the same database instance as the E-Business Suite.  AA may be purchased with extensions and auditor-reviewed seeded content designed for E-Business Suite, which support SOX and SOD audit functions.

Additionally, AA has several default configuration features such as capturing the EBS FND User name and Responsibility in use when a transaction occurs.